EVs Extracellular Vesicles

Extracellular vesicle (EVs), natural biological messengers, are unlocking new therapeutic possibilities with their ability to deliver biomolecules with precision. The production of EVs is rapidly emerging as a significant area of interest, with researchers and companies eveloping innovative methods to isolate, purify, and engineer these vesicles for specific applications (cancers, immune disorders, inflammatory diseases).

• For process development scientists, Videodrop is an ideal tool to establish an optimized production and purification process. With yield calculations and recovery analysis, it becomes easy to refine each step of the EVs bioproduction process.
• The speed and ease of use of the Videodrop enable real-time in-process controls for EVs bioproduction directly on the production line.
• Moreover, Videodrop is relevant in stability study to optimize buffer and storage conditions.
• The system’s absence of fluidic components makes it the only one capable of measuring EVs in viscous samples such as hydrogel.

Extracellular vesicles (EVs) are emerging as novel biomarkers for various diseases, including cancer and inflammation. In both fundamental and translational research, but also clinical trials, the development and implementation of standardized methodologies for EVs quantification are essential for reliable results.

ADVANTAGES

• Thanks to its high repeatability and reproducibility, Videodrop is particularly adapted for longitudinal studies in translational research and clinical studies. Cohorts, including a high number of patients, can be easily analyzed using Videodrop after a short EVs isolation protocol.
• Videodrop concentrations can be used as a standard concentration to normalize high-end analysis and multi-omics approach.